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. 2017 Jan 20;12(1):e0170253.
doi: 10.1371/journal.pone.0170253. eCollection 2017.

Changes in Molecular Characteristics of Mycoplasma pneumoniae in Clinical Specimens from Children in Beijing between 2003 and 2015

Hongmei Sun  1 , Guanhua Xue  1 , Chao Yan  1 , Shaoli Li  1 , Hanqing Zhao  1 , Yanling Feng  1 , Liqiong Wang  1
Affiliations

Changes in Molecular Characteristics of Mycoplasma pneumoniae in Clinical Specimens from Children in Beijing between 2003 and 2015

Hongmei Sun et al. PLoS One. .

Abstract

The molecular characteristics of 480 Mycoplasma pneumoniae polymerase chain reaction-positive specimens (331 were previously reported and 149 were newly reported) collected from pediatric patients in Beijing, China, between 2003 and 2015 were analyzed. Genotype M4-5-7-2/P1 were the most prevalent across the 13-year study period, although the isolation and mutation rates for this genotype varied between the periods 2003-2007, 2008-2013, and 2014-2015. In addition, there was a close association between the M4-5-7-2 genotype and macrolide resistance.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Prevalence rates of the different genotypes and macrolide resistance mutations by year.
(A) Prevalence of the different P1genotypes from 2003–2015. (B) Prevalence of the different MLVA genotypes from 2003–2015. (C) Prevalence of macrolide resistance mutations from 2003–2015.
Fig 2
Fig 2. Relationship between MLVA type and the presence of macrolide resistance mutations from 2003–2015.
See this image and copyright information in PMC

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