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. 2017 Jan 19;24(1):1-2.
doi: 10.1016/j.chembiol.2017.01.001.

One Ring to Fight Them All: The Sulfazecin Story

Daniel Braga  1 , Gerald Lackner  2
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Free article

One Ring to Fight Them All: The Sulfazecin Story

Daniel Braga et al. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Li et al. (2017) report on the biosynthesis of the monobactam sulfazecin by Pseudomonas acidophila and hypothesize a novel mechanism of β-lactam ring formation. As monobactam antibiotics are unaffected by some emerging resistance mechanisms (particularly metallo-β-lactamases), this discovery opens prospects to engineer β-lactam antibiotics against multi-drug resistant pathogens.

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