[Analysis of therapeutic factors related to survival rate for malignant glioma patients--report from Brain Tumor Registry in Japan, Vol. 6, 1987]

Abstract

From the data in vol. 6 of Brain Tumor Registry in Japan, there were mainly analyzed the survival rates of malignant astrocytoma and glioblastoma patients related to extent of surgical removal and postoperative radiation. Total removal of the supratentorial astrocytoma in brain revealed 75.9% in 5-year survival rate, whereas supratentorial malignant astrocytomas and glioblastomas, 43.7% and 20.9% in 5-year survival rates, respectively. Survival rates related to combination of operation and radiation therapy for the glioblastoma and malignant astrocytoma patients were analyzed according to the mode of operation. For glioblastomas, patients treated with biopsy and post-operative radiation therapy indicated higher survival rate of 6.3% in 5-year survival than the patients with biopsy and no radiation, 3.0% of 5-year survival rates (P less than 0.01 by Chi-square test). On the other hand, patients treated with 95%-100% removal by operation with or without radiation therapy showed 67.2% (with), 32.1% (without) in 1 year survival; 37.2%, 23.1% in 2 year survival; 27.1%, 20.0% in 3 year survival; 22.5%, 20.2% in 4 year survival and 20.4% and 19.4% in 5-year survival rates, respectively (P less than 0.05 by Chi-square test). Tentative TNM classification proposed by Japan to UICC was also discussed briefly.