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. 2017;311(1):727-732.
doi: 10.1007/s10967-016-5073-1. Epub 2016 Oct 24.

Radiosynthesis of no-carrier-added meta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma

Michael Green  1 , Jonathan Lowe  1 , Manikandan Kadirvel  1 , Adam McMahon  1 , Nigel Westwood  2 , Sue Chua  3 , Gavin Brown  1
Affiliations

Radiosynthesis of no-carrier-added meta-[124I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma

Michael Green et al. J Radioanal Nucl Chem. 2017.

Abstract

Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [124I] for a proof of concept study to assess the diagnostic accuracy of [124I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [124I]sodium iodide and meta-trimethylsilylbenzylguanidine. [124I]mIBG was produced in 62-70 % radioiodide incorporation yield from [124I]sodium iodide. The average amount of formulated [124I]mIBG was 359 MBq (range 344-389 MBq) with an average specific radioactivity of 4.1 TBq μmol-1 (range 1.8-5.9 TBq μmol-1) at end of synthesis.

Keywords: Meta-iodobenzylguanidine; Neuroblastoma; Positron emission tomography; Radiochemistry; [124I]; mIBG.

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Figures

Scheme 1
Scheme 1
Synthesis of radioiodinated meta-iodobenzylguanidines
Fig. 1
Fig. 1
A typical HPLC chromatogram from the radiosynthesis of [124I]mIBG
See this image and copyright information in PMC

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