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Review
. 2017 Jan 12;17(1):e6839.
doi: 10.5867/medwave.2017.01.6839.

[Pathophysiology of diabetic nephropathy: a literature review]

[Article in Spanish]
Carlos Eduardo Meza Letelier  1 , Camilo Alfredo San Martín Ojeda  2 , José Javier Ruiz Provoste  2 , Cristobal Jesus Frugone Zaror  2
Affiliations
Review

[Pathophysiology of diabetic nephropathy: a literature review]

[Article in Spanish]
Carlos Eduardo Meza Letelier et al. Medwave. .

Abstract
in English, Spanish

Chronic kidney disease is a common complication of diabetes. Its importance lies in its high prevalence and future projection. It is associated with high health costs and global cardiovascular deterioration as well. The development of this disease pathophysiology is being studied and it is known that a series of complex molecular pathways determining a microvascular disease are involved. This review addresses the known pathways in the development of diabetic nephropathy aiming to improve the understanding of potential therapeutic targets that could be developed in the future.

La enfermedad renal crónica es una complicación frecuente en la diabetes mellitus. Su importancia radica en la alta prevalencia y la proyección a futuro que ésta tiene. Se asocia a altos gastos en salud y además a deterioro cardiovascular global. La fisiopatología del desarrollo de esta enfermedad está siendo estudiada y se sabe que en ella participan una serie de vías moleculares complejas que determinan una enfermedad microvascular. En esta revisión se intenta abordar las vías conocidas en el desarrollo de nefropatía diabética, con el fin de comprender mejor posibles blancos terapéuticos que se podrían desarrollar.

Keywords: chronic renal disease physiopathology; microvascular complications; diabetic nephropathy.

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