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. 2017 Feb 1;139(4):1428-1431.
doi: 10.1021/jacs.6b12443. Epub 2017 Jan 23.

Enantioselective Synthesis of [6]Carbohelicenes

Elisa González-Fernández  1 , Leo D M Nicholls  1 , Lukas D Schaaf  1 , Christophe Farès  2 , Christian W Lehmann  2 , Manuel Alcarazo  1
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Enantioselective Synthesis of [6]Carbohelicenes

Elisa González-Fernández et al. J Am Chem Soc. .

Abstract

The use of α-cationic phosphonites derived from TADDOL as ancillary ligands has allowed a highly regio- and enantioselective synthesis of substituted [6]carbohelicenes by sequential Au-catalyzed intramolecular hydroarylation of diynes. Key for these results is the modular structure of these new ligands, and the enhanced reactivity that they impart to Au(I)-centers after coordination.

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