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. 2017 Mar 23;85(4):e00035-17.
doi: 10.1128/IAI.00035-17. Print 2017 Apr.

Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii

Beth A Garvy  1
Affiliations

Overcoming Hurdles to Development of a Vaccine against Pneumocystis jirovecii

Beth A Garvy. Infect Immun. .

Abstract

Development of Pneumocystis pneumonia (PCP) is a common problem among immunosuppressed individuals. There are windows of opportunity in which vaccination would be beneficial, but to date, no vaccines have made it to clinical trials. Significant hurdles to vaccine development include host range specificity, making it difficult to translate from animal models to humans. Discovery of cross-reactive epitopes is critical to moving vaccine candidates from preclinical animal studies to clinical trials.

Keywords: Pneumocystis carinii; vaccines.

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References

    1. Tesini BL, Wright TW, Malone JE, Haidaris CG, Harber M, Sant AJ, Nayak JL, Gigliotti F. 2017. Immunization with Pneumocystis cross-reactive antigen 1 (Pca1) protects mice against Pneumocystis pneumonia and generates antibody to Pneumocystis jirovecii. Infect Immun 85:e00850-16. doi:10.1128/IAI.00850-16. - DOI - PMC - PubMed
    1. Gajdusek DC. 1957. Pneumocystis carinii; etiologic agent of interstitial plasma cell pneumonia of premature and young infants. Pediatrics 19:543–565. - PubMed
    1. Anderson KC, Soiffer R, DeLage R, Takvorian T, Freedman AS, Rabinowe SL, Nadler LM, Dear K, Heflin L, Mauch P. 1990. T-cell-depleted autologous bone marrow transplantation therapy: analysis of immune deficiency and late complications. Blood 76:235–244. - PubMed
    1. Murphy JL, Kano HL, Chenaille PJ, Makker SP. 1993. Fatal Pneumocystis pneumonia in a child treated for focal segmental glomerulosclerosis. Pediatr Nephrol 7:444–445. doi:10.1007/BF00857565. - DOI - PubMed
    1. Siegel SE, Nesbit ME, Baehner R, Sather H, Hammond GD. 1980. Pneumonia during therapy for childhood acute lymphoblastic leukemia. Am J Dis Child 134:28–34. - PubMed

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