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Review
. 2016:2016:8590578.
doi: 10.1155/2016/8590578. Epub 2016 Dec 27.

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review

Shanmugam Manoharan  1 , Gilles J Guillemin  2 , Rajagopal Selladurai Abiramasundari  1 , Musthafa Mohamed Essa  3 , Mohammed Akbar  4 , Mohammed D Akbar  4
Affiliations
Review

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease: A Mini Review

Shanmugam Manoharan et al. Oxid Med Cell Longev. 2016.

Abstract

Neurodegenerative diseases affect not only the life quality of aging populations, but also their life spans. All forms of neurodegenerative diseases have a massive impact on the elderly. The major threat of these brain diseases includes progressive loss of memory, Alzheimer's disease (AD), impairments in the movement, Parkinson's disease (PD), and the inability to walk, talk, and think, Huntington's disease (HD). Oxidative stress and mitochondrial dysfunction are highlighted as a central feature of brain degenerative diseases. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status, has been known to play a vital role in the pathophysiology of neurodegenerative diseases including AD, PD, and HD. A large number of studies have utilized oxidative stress biomarkers to investigate the severity of these neurodegenerative diseases and medications are available, but these only treat the symptoms. In traditional medicine, a large number of medicinal plants have been used to treat the symptoms of these neurodegenerative diseases. Extensive studies scientifically validated the beneficial effect of natural products against neurodegenerative diseases using suitable animal models. This short review focuses the role of oxidative stress in the pathogenesis of AD, PD, and HD and the protective efficacy of natural products against these diseases.

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Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
The causes of oxidative stress in Alzheimer's disease.
Figure 2
Figure 2
The causes of oxidative stress in Parkinson's disease.
Figure 3
Figure 3
The causes of oxidative stress in Huntington's disease.
See this image and copyright information in PMC

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