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. 1989 Oct;24(10):854-8.
doi: 10.1007/BF02535759.

Effect of phosphatidylcholine on the alpha-lactalbumin-induced fusion of vesicles

B S Park  1 , J Kim, U H Kim, H Kim
Affiliations

Effect of phosphatidylcholine on the alpha-lactalbumin-induced fusion of vesicles

B S Park et al. Lipids. 1989 Oct.

Abstract

Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin. It was found that inclusion of phosphatidylcholine in the vesicles results in a depression of fusion. This depression of fusion appears to be caused by a reduction in the amount of irreversibly bound alpha-lactalbumin to vesicles containing phosphatidylcholine. It is suggested that in this system fusion is dependent upon the extent by which a particular protein segment penetrates the bilayer.

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