Genetics and genomics etiology of nonsyndromic orofacial clefts
- PMID: 28116324
- PMCID: PMC5241211
- DOI: 10.1002/mgg3.272
Genetics and genomics etiology of nonsyndromic orofacial clefts
Abstract
Orofacial clefts (OFC) are complex birth defects. Studies using contemporary genomic techniques, bioinformatics, and statistical analyses have led to appreciable advances in identifying the causes of syndromic forms of clefts. This commentary gives an overview of the important cleft gene discoveries found using various genomic methods and tools.
References
-
- Alkuraya, F. S. , Saadi I., Lund J. J., Turbe‐Doan A., Morton C. C., and Maas R. L.. 2006. SUMO1 haploinsufficiency leads to cleft lip and palate. Science 313:1751. - PubMed
-
- Beaty, T. H. , Murray J. C., Marazita M. L., Munger R. G., Ruczinski I., Hetmanski J. B., et al. 2010. A genome wide association study of cleft lip with / without cleft palate using case‐parent trios of European and Asian ancestry identifies MAFB and ABCA4 as novel candidate genes. Nat. Genet. 42:525–529. - PMC - PubMed
-
- Bille, C. , Olsen J., Vach W., Knudsen V. K., Olsen S. F., Rasmussen K., et al. 2007. Oral clefts and life style factors–a case‐cohort study based on prospective Danish data. Eur. J. Epidemiol. 22:173–181. - PubMed
-
- Birnbaum, S. , Ludwig K. U., Reutter H., Herms S., Steffens M., Rubini M., et al. 2009. Key susceptibility locus for nonsyndromic cleft lip with or withgout cleft palate on chromosome 8q24. Nat. Genet. 41:473–477. - PubMed
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