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. 2017 Mar;29(12).
doi: 10.1002/adma.201605497. Epub 2017 Jan 24.

Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window

Qinglai Yang  1   2 , Zhuoran Ma  3 , Huasen Wang  1 , Bin Zhou  4 , Shoujun Zhu  3 , Yeteng Zhong  3 , Junying Wang  5 , Hao Wan  1   3 , Alexander Antaris  3 , Rui Ma  1 , Xiao Zhang  1 , Jingyi Yang  1 , Xiaodong Zhang  5 , Haitao Sun  4 , Weiqiang Liu  2 , Yongye Liang  1 , Hongjie Dai  3
Affiliations

Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window

Qinglai Yang et al. Adv Mater. 2017 Mar.

Abstract

A new design for second near-infrared window (NIR-II) molecular fluorophores based on a shielding unit-donor-acceptor-donor-shielding unit (S-D-A-D-S) structure is reported. With 3,4-ethylenedioxy thiophene as the donor and fluorene as the shielding unit, the best performance fluorophores IR-FE and IR-FEP exhibit an emission quantum yield of 31% in toluene and 2.0% in water, respectively, representing the brightest organic dyes in NIR-II region reported so far.

Keywords: 3,4-ethylenedioxy thiophene; biological imaging; fluorine; molecular fluorophores; second near-infrared window.

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