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Meta-Analysis
. 2017 May-Jun;22(3-4):200-209.
doi: 10.1080/1354750X.2017.1286689. Epub 2017 Feb 14.

Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis

Benedetta Piccardi  1 , Dolors Giralt  2 , Alejandro Bustamante  2 , Victor Llombart  2 , Teresa García-Berrocoso  2 , Domenico Inzitari  1   3 , Joan Montaner  2
Affiliations
Meta-Analysis

Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis

Benedetta Piccardi et al. Biomarkers. 2017 May-Jun.

Abstract

Context: Various processes including inflammation and endothelial dysfunction have been implicated in the pathogenesis of cardioembolic (CE) strokes.

Objective: To review the evidence and investigate the association between immune-inflammatory biomarkers and CE strokes versus other stroke subtypes.

Methods: We systematically reviewed the literature (sources: MEDLINE, web-based register http://stroke-biomarkers.com , reference lists) with quality assessment and meta-analysis of selected articles.

Results: The most consistent association was found between C-reactive protein (CRP) and CE strokes when compared to other stroke subtypes (standardized mean difference 0.223 (0.116, 0.343); p < 0.001) Conclusions: Our findings confirm a possible association between selected inflammatory biomarkers and CE stroke.

Keywords: Cardiovascular disease; biological markers; stroke.

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