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Review
. 2017 Jan 21;8(1):3.
doi: 10.3390/jfb8010003.

Minimizing Skin Scarring through Biomaterial Design

Alessandra L Moore  1   2 , Clement D Marshall  3 , Michael T Longaker  4   5
Affiliations
Review

Minimizing Skin Scarring through Biomaterial Design

Alessandra L Moore et al. J Funct Biomater. .

Abstract

Wound healing continues to be a major burden to patients, though research in the field has expanded significantly. Due to an aging population and increasing comorbid conditions, the cost of chronic wounds is expected to increase for patients and the U.S. healthcare system alike. With this knowledge, the number of engineered products to facilitate wound healing has also increased dramatically, with some already in clinical use. In this review, the major biomaterials used to facilitate skin wound healing will be examined, with particular attention allocated to the science behind their development. Experimental therapies will also be evaluated.

Keywords: biomaterials; scar; tissue engineering; wound healing.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Sen C.K., Gordillo G.M., Roy S., Kirsner R., Lambert L., Hunt T.K., Gottrup F., Gurtner G.C., Longaker M.T. Human skin wounds: A major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17:763–771. doi: 10.1111/j.1524-475X.2009.00543.x. - DOI - PMC - PubMed
    1. Singer A.J., Clark R.A. Cutaneous wound healing. N. Engl. J. Med. 1999;341:738–746. - PubMed
    1. Ahn S.T., Monafo W.W., Mustoe T.A. Topical silicone gel for the prevention and treatment of hypertrophic scar. Arch. Surg. 1991;126:499–504. doi: 10.1001/archsurg.1991.01410280103016. - DOI - PubMed
    1. Asilian A., Darougheh A., Shariati F. New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol. Surg. 2006;32:907–915. - PubMed
    1. Henshaw F.R., Boughton P., Lo L., McLennan S.V., Twigg S.M. Topically applied connective tissue growth factor/CCN2 improves diabetic preclinical cutaneous wound healing: Potential role for CTGF in human diabetic foot ulcer healing. J. Diabetes Res. 2015;2015 doi: 10.1155/2015/236238. - DOI - PMC - PubMed

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