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Review
. 2017 Apr;45(2):80-86.
doi: 10.1249/JES.0000000000000106.

Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms

Sophie Carter  1 , Yvonne Hartman, Sophie Holder, Dick H Thijssen, Nicola D Hopkins
Affiliations
Review

Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms

Sophie Carter et al. Exerc Sport Sci Rev. 2017 Apr.

Abstract

Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.

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