Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Nov;69(11):1743-1750.
doi: 10.1002/acr.23198. Epub 2017 Sep 21.

Predictors of Reduced Health-Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies

Michal Feldon  1 , Payam Noroozi Farhadi  2 , Hermine I Brunner  1 , Lukasz Itert  1 , Bob Goldberg  3 , Abdullah Faiq  2 , Jesse Wilkerson  4 , Kathryn M Rose  4 , Lisa G Rider  2 , Frederick W Miller  2 , Edward H Giannini  1
Affiliations

Predictors of Reduced Health-Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies

Michal Feldon et al. Arthritis Care Res (Hoboken). 2017 Nov.

Abstract

Objective: Extensive studies on health-related quality of life (HRQoL) in idiopathic inflammatory myopathies (IIMs) are lacking. Our objective was to document HRQoL and to identify factors associated with a reduced HRQoL in patients with IIM.

Methods: A total of 1,715 patients (median age 49.9 years, 70% female, 87% white) who met probable or definite Bohan and Peter criteria or Griggs criteria for myositis were included from the Myovision registry. HRQoL was ascertained using the Short Form 12 (SF-12) health survey questionnaire. HRQoL physical component summary (PCS) and mental component summary (MCS) scores in relation to different patient and disease characteristics were compared to scores from matched normative data from the US general population and rheumatoid arthritis (RA) patients. Bivariate and multiple linear regression analyses were performed to assess the association between HRQoL and patient and disease parameters.

Results: The mean SF-12 summary scores were significantly lower in IIM patients than in the normative and RA populations. A diagnosis of inclusion body myositis, older age, patient-reported negative effect of disease on work, presence of another co-occurring autoimmune disease, polypharmacy, and IIM-associated lung disease and joint involvement were significantly associated with lower PCS scores. Lower MCS scores were associated with joint involvement and a negative effect of disease on work.

Conclusion: In this large study of patient-reported outcomes in IIM, an association was found between multiple disease characteristics and reduced HRQoL, mostly in the physical domain. In the US, the HRQoL of IIM patients was found to be lower than that of the general population and RA patients.

PubMed Disclaimer

Conflict of interest statement

Financial disclosure/Conflicts of interest: Nothing to disclose

Figures

Figure 1
Figure 1
Flow diagram for patient inclusion in the study
See this image and copyright information in PMC

References

    1. Dalakas MC. Inflammatory muscle diseases. New Engl. J. Medicine. 2015;372(18):1734–1747. - PubMed
    1. Briani C, Doria A, Sarzi-Puttini P, Dalakas MC. Update on idiopathic inflammatory myopathies. Autoimmunity. 2006;39(3):161–170. - PubMed
    1. Bronner IM, van der Meulen MF, de Visser M, Kalmijn S, van Venrooij WJ, Voskuyl AE, et al. Long-term outcome in polymyositis and dermatomyositis. Annals of the Rheumatic Diseases. 2006;65(11):1456–1461. - PMC - PubMed
    1. Armadans-Tremolosa I, Selva-O’Callaghan A, Visauta-Vinacua B, Guilera G, Pinal-Fernandez I, Vilardell-Tarres M. Health-related quality of life and well-being in adults with idiopathic inflammatory myopathy. Clinical Rheumatology. 2014;33(8):1119–1125. - PubMed
    1. Goreshi R, Chock M, Foering K, Feng R, Okawa J, Rose M, et al. Quality of life in dermatomyositis. Journal of the American Academy of Dermatology. 2011;65(6):1107–1116. - PMC - PubMed

Publication types