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Comment
. 2017 Jan 23;40(2):118-119.
doi: 10.1016/j.devcel.2017.01.004.

Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis

Aaron M Hosios  1 , Matthew G Vander Heiden  2
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Free article
Comment

Endothelial Cells Get β-ox-ed In to Support Lymphangiogenesis

Aaron M Hosios et al. Dev Cell. .
Free article

Abstract

Acetyl-CoA has diverse fates in metabolism and can be derived from a variety of nutrients. In a recent study published in Nature, Wong et al. (2016) show that endothelial cells oxidize fatty acids to produce acetyl-CoA for epigenetic modifications critical to lymphangiogenesis.

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  • The role of fatty acid β-oxidation in lymphangiogenesis.
    Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P. Wong BW, et al. Nature. 2017 Feb 2;542(7639):49-54. doi: 10.1038/nature21028. Epub 2016 Dec 26. Nature. 2017. PMID: 28024299

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