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Meta-Analysis
. 2017 Jul 4;8(27):44811-44818.
doi: 10.18632/oncotarget.14757.

Safety and efficacy of canaloplasty versus trabeculectomy in treatment of glaucoma

Haifeng Liu  1 , Haitao Zhang  2 , Yanhua Li  1 , Han Yu  1
Affiliations
Meta-Analysis

Safety and efficacy of canaloplasty versus trabeculectomy in treatment of glaucoma

Haifeng Liu et al. Oncotarget. .

Abstract

We assess the efficacy and safety of canaloplasty and trabeculectomy for treatment of glaucoma. We searched the China National Knowledge Infrastructure, PubMed, Web of Science, and WanFang databases for potentially eligible studies. Pooled risk ratio (RR) with 95% confidence interval (CI) was calculated using random- or fixed-effect models if appropriate. Eight studies were included for meta-analysis. There was no difference in intraocular pressure at 6 months (WMD = 0.97, 95%CI: -0.48-2.41). Intraocular pressure in canaloplasty group 12 months after operation was higher than in trabeculectomy group (WMD = 1.90, 95%CI: 0.12-3.69), P < 0.05). The canaloplasty group showed higher success rate than trabeculectomy group (RR = 0.86, 95%CI: 0.77-0.97). The canaloplasty group was more likely to have hyphema (RR = 2.96, 95%CI: 1.51-5.83), P < 0.05) than trabeculectomy group (RR = 0.24, 95, CI(0.06-0.89), P < 0.05]. The incidence of and hypotony and postoperative choroid abnormalities in canaloplasty group was significantly lower than that in trabeculectomy group (RR = 0.30, 95%CI: 0.11-0.83; RR = 0.24, 95%CI: 0.09-0.66), P < 0.05). Both trabeculectomy and canaloplasty can significantly reduce the intraocular pressure in glaucoma patients at 12 months after operation, trabeculectomy leads a more marked IOP decrease than canaloplasty at the cost of a higher complication rate and more demanding for postoperative care.

Keywords: canaloplasty; glaucoma; meta-analysis; trabeculectomy.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1. The process of study selection
Figure 2
Figure 2. Forest plot of intraocular pressure at 6 and 12 months after operations
Figure 3
Figure 3. Succus rate of intraocular pressure control between two group
Figure 4
Figure 4. Forest plot of complications risk between two group
Figure 5
Figure 5. Funnel plot for publication bias assessment
See this image and copyright information in PMC

References

    1. Netland PA. Nonpenetrating glaucoma surgery. Ophthalmology. 2001;108:416–421. - PubMed
    1. Cairns JE. Trabeculectomy. Preliminary report of a new method. AM J Ophthalmol. 1968;66:673–679. - PubMed
    1. Razeghinejad MR, Fudemberg SJ, Spaeth GL. The changing conceptual basis of trabeculectomy: a review of past and current surgical techniques. Surv Ophthalmol. 2012;57:1–25. - PubMed
    1. Kaplowitz K, Nobe M, Abazari A, Honkanen R. Trabeculectomy for traumatic hyphema in sickle cell trait. Semin Ophthalmol. 2015;30:297–304. - PubMed
    1. Nakatake S, Yoshida S, Nakao S, Arita R, Yasuda M, Kita T, Enaida H, Ohshima Y, Ishibashi T. Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma: a retrospective analysis. BMC Ophthalmol. 2014;14:55. - PMC - PubMed

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