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Meta-Analysis
. 2017 Apr 4;8(14):23927-23936.
doi: 10.18632/oncotarget.14760.

Prognostic value of abnormally expressed lncRNAs in ovarian carcinoma: a systematic review and meta-analysis

Ping Luo  1 , Xue-Fang Liu  1 , Ying-Chao Wang  1 , Nan-Di Li  1 , Shen-Jun Liao  1 , Ming-Xia Yu  1 , Chun-Zi Liang  1 , Jian-Cheng Tu  1
Affiliations
Meta-Analysis

Prognostic value of abnormally expressed lncRNAs in ovarian carcinoma: a systematic review and meta-analysis

Ping Luo et al. Oncotarget. .

Abstract

Ovarian cancer (OC) is the most deadly gynecological cancer and it is urgently needed to find a new marker for the progress of OC. Many long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in ovarian carcinoma, and may serve as prognostic markers. Therefore, we conducted this meta-analysis to gain a better understanding of the prognostic value of lncRNAs in patients with varian carcinoma. We systematically searched PubMed, EMBASE, and Web of Science. A total of 13 eligible studies, including 10 on clinicopathological features, 13 on prognosis were identified. Pooled hazard ratios (HRs) or odds ratios (OR) and 95% confidence intervals (95% CIs) were calculated using random- or fixed-effects models. Our results revealed that the increased expressions of 8 lncRNAs were associated with poor prognosis and the decreased expressions of 5 lncRNAs were related to poor prognosis in ovarian carcinoma. High HOTAIR expression was associated with shorter overall survival in ovarian cancer (pooled HR: 2.05, 95% CI: 1.51-2.77, P < 0.001). In conclusion, our meta-analysis suggested that LncRNAs could function as potential prognostic markers for ovarian cancer patients and high expression HOTAIR was associated with shorter overall survival in ovarian cancer.

Keywords: long noncoding RNAs; meta-analysis; ovarian cancer; overall survival; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1. Flow diagram of study selection process
Figure 2
Figure 2. Forest plots of studies evaluating odds ratios (ORs) of HOTAIR expression and the clinicopathology of OC patients
Figure 3
Figure 3. A display of Hazard ratios (HRs) of lncRNAs in OC patients
The point estimate is bounded by a 95% confidence interval, and the perpendicular line represents no increased risk for the outcome. OC: ovarian cancer.
Figure 4
Figure 4. Forest plots for the association between HOTAIR expression and OS of OC patients
The point estimate is bounded by a 95% confidence interval, and the perpendicular line represents no increased risk for the outcome. OS: overall survival; OC: ovarian cancer.
Figure 5
Figure 5. Sensitivity analysis of the influence of each individual study on the pooled HRs by omitting individual studies
See this image and copyright information in PMC

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