Energy Metabolism and Ageing in the Mouse: A Mini-Review

Abstract

The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains. Mouse models have provided great insights into the ageing process, which in its broadest sense is the progressive decline of body functions over time. In this mini-review, we briefly cover the historical views on the link between ageing and metabolic rate, highlight genetically modified transgenic mouse models of extended lifespan, discuss endocrine pathways linked to senescence and ageing, and then examine pathways by which caloric restriction is postulated to result in longevity.

Keywords: Ageing; Caloric restriction; Comparative biology; Energy metabolism; Genetic mouse models of extended lifespan; Growth hormone signalling; Insulin; Insulin-like growth factor-1; Laboratory mice; Longevity pathways.