Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

Alan Daugherty^{1

2}, Zheying Chen^{3

2}, Hisashi Sawada³, Debra L Rateri³, Mary B Sheppard^{3

4

5}

Affiliations

¹ Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY alan.daugherty@uky.edu.
² Department of Physiology, University of Kentucky, Lexington, KY.
³ Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY.
⁴ Department of Family Medicine, University of Kentucky, Lexington, KY.
⁵ Department of Surgery, University of Kentucky, Lexington, KY.

Editorial

Alan Daugherty et al. J Am Heart Assoc. 2017.

. 2017 Jan 24;6(1):e005221.

doi: 10.1161/JAHA.116.005221.

Alan Daugherty^{1

2}, Zheying Chen^{3

2}, Hisashi Sawada³, Debra L Rateri³, Mary B Sheppard^{3

4

5}

¹ Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY alan.daugherty@uky.edu.
² Department of Physiology, University of Kentucky, Lexington, KY.
³ Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY.
⁴ Department of Family Medicine, University of Kentucky, Lexington, KY.
⁵ Department of Surgery, University of Kentucky, Lexington, KY.

No abstract available

Keywords: Editorials; aneurysm; cytokine; transforming growth factor‐β pathway aneurysm; vascular biology.

Comment on

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.
Wei H, Hu JH, Angelov SN, Fox K, Yan J, Enstrom R, Smith A, Dichek DA. Wei H, et al. J Am Heart Assoc. 2017 Jan 24;6(1):e004968. doi: 10.1161/JAHA.116.004968. J Am Heart Assoc. 2017. PMID: 28119285 Free PMC article.

1. Dietz HC, Cutting CR, Pyeritz RE, Maslen CL, Sakai LY, Corson GM, Puffenberger EG, Hamosh A, Nanthakumar EJ, Curristin SM, Setten G, Meyers DA, Francomano CA. Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene. Nature. 1991;352:337–339. - PubMed
1. Wu D, Shen YH, Russell L, Coselli JS, LeMaire SA. Molecular mechanisms of thoracic aortic dissection. J Surg Res. 2013;184:907–924. - PMC - PubMed
1. Milewicz DM, Dietz HC, Miller DC. Treatment of aortic disease in patients with Marfan syndrome. Circulation. 2005;111:e150–e157. - PubMed
1. Lindsay ME, Dietz HC. Lessons on the pathogenesis of aneurysm from heritable conditions. Nature. 2011;473:308–316. - PMC - PubMed
1. Wei H, Hu JH, Angelov SN, Fox K, Ysan J, Enstrom R, Smith A, Dichek DA. Aortopathy in a mouse model of Marfan syndrome is not mediated by altered transforming growth factor β signaling. J Am Heart Assoc. 2017;5:e004968 DOI: 10.1161/JAHA.116.004968. - DOI - PMC - PubMed