Will genetic studies deliver the next generation of cardioprotective therapies?

Affiliations

¹ 1 South Australian Health and Medical Research Institute, University of Adelaide, Australia.
² 2 Imperial College London, UK.
³ 3 Julius Center for Health Sciences and Primary Care and Julius Clinical Research, University Medical Center Utrecht, the Netherlands.

Free article

Editorial

Stephen J Nicholls et al. Eur J Prev Cardiol. 2017 Mar.

Free article

. 2017 Mar;24(5):489-491.

doi: 10.1177/2047487317690960. Epub 2017 Jan 25.

¹ 1 South Australian Health and Medical Research Institute, University of Adelaide, Australia.
² 2 Imperial College London, UK.
³ 3 Julius Center for Health Sciences and Primary Care and Julius Clinical Research, University Medical Center Utrecht, the Netherlands.

No abstract available

Comment on

Genetic invalidation of Lp-PLA₂ as a therapeutic target: Large-scale study of five functional Lp-PLA₂-lowering alleles.
Gregson JM, Freitag DF, Surendran P, Stitziel NO, Chowdhury R, Burgess S, Kaptoge S, Gao P, Staley JR, Willeit P, Nielsen SF, Caslake M, Trompet S, Polfus LM, Kuulasmaa K, Kontto J, Perola M, Blankenberg S, Veronesi G, Gianfagna F, Männistö S, Kimura A, Lin H, Reilly DF, Gorski M, Mijatovic V; CKDGen consortium; Munroe PB, Ehret GB; International Consortium for Blood Pressure; Thompson A, Uria-Nickelsen M, Malarstig A, Dehghan A; CHARGE inflammation working group; Vogt TF, Sasaoka T, Takeuchi F, Kato N, Yamada Y, Kee F, Müller-Nurasyid M, Ferrières J, Arveiler D, Amouyel P, Salomaa V, Boerwinkle E, Thompson SG, Ford I, Wouter Jukema J, Sattar N, Packard CJ, Shafi Majumder AA, Alam DS, Deloukas P, Schunkert H, Samani NJ, Kathiresan S; MICAD Exome consortium; Nordestgaard BG, Saleheen D, Howson JM, Di Angelantonio E, Butterworth AS, Danesh J; EPIC-CVD consortium and the CHD Exome+ consortium. Gregson JM, et al. Eur J Prev Cardiol. 2017 Mar;24(5):492-504. doi: 10.1177/2047487316682186. Epub 2016 Dec 8. Eur J Prev Cardiol. 2017. PMID: 27940953 Free PMC article.