Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Feb 14;8(7):10773-10774.
doi: 10.18632/oncotarget.14604.

The Tat-Aβ1-6A2V(D) peptide against AD synaptopathy

Lucia Buccarello  1 , Tiziana Borsello  1
Affiliations
Editorial

The Tat-Aβ1-6A2V(D) peptide against AD synaptopathy

Lucia Buccarello et al. Oncotarget. .
No abstract available

Keywords: Neuroscience; cell permeable peptide; neurodegenerative diseases; neuroprotection; synaptic dysfunction.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Schematic diagram of the general structure of the excitatory synapses
Excitatory synapses are composed by the pre- and post-synaptic elements. In the post-synaptic element there is a specialization of the cell membrane called the postsynaptic density region (PSD), this zone contains a large number of scaffolding proteins. Among these proteins, PSD-95 is the more abundant and plays an important role in the localization of AMPA (red channels) and NMDA (green channel) receptors. Slight perturbations of the spine architecture lead to spine dysfunction and subsequently loss. The mechanism underling synaptic dysfunction is characterized by an initial reversible stage with a slight reduction of PSD-95 protein, NMDA and AMPA receptors that induces a synaptic dysfunction. Afterwards, a major decrease of PSD-95 occurs inducing an atrophy of the post-synaptic element that generate synaptic loss and eventually neuronal death.
See this image and copyright information in PMC

References

    1. Di Fede G., et al. Science. 2009;323:1473–7. - PMC - PubMed
    1. Sclip A, et al. J Mol Cell Biol. 2013;5:277–9. - PubMed
    1. Messa M, et al. J Biol Chem. 2014;289:24143–52. - PMC - PubMed
    1. Cimini S, et al. Neurobiol Dis. 2016;89:101–11. - PubMed
    1. Kim J, et al. PLoS One 8. 2013;8:e77972. - PMC - PubMed

Publication types