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. 1989 Sep-Oct;10(5):429-31; discussion 446-8.
doi: 10.1016/0197-4580(89)90084-5.

Modelling the occurrence and pathology of Alzheimer's disease

J A Hardy  1 , A M Goate, M J Owen, M J Mullan, M N Rossor, R C Pearson
Affiliations

Modelling the occurrence and pathology of Alzheimer's disease

J A Hardy et al. Neurobiol Aging. 1989 Sep-Oct.

Abstract

Our work has confirmed that of St. George-Hyslop and colleagues, suggesting FAD linkage to the short arm of chromosome 21 in outbred families with a presenile onset of the disease. Future genetic studies should help clarify the current apparent discrepancies between certain laboratories and ultimately lead to a better understanding of the variables which predispose individuals to the disease.

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