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. 1989 Sep-Oct;10(5):631; discussion 648-50.
doi: 10.1016/0197-4580(89)90156-5.

Site-specific drug delivery to CNS: old and new

L E Hollister  1
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Site-specific drug delivery to CNS: old and new

L E Hollister. Neurobiol Aging. 1989 Sep-Oct.

Abstract

Delivery of drugs to specific sites in the CNS represents an essential therapeutic challenge. Extradural administration of opiates successfully delivers drugs to the CNS. The levodopa-carbidopa combination achieved some degree of site-specific delivery by pharmacological methods. Antibiotics have been administered through cannula directly into ventricles. Invasive methods offer the greatest degree of site-specificity.

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