Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2016 Dec 1;51(4):228-230.
doi: 10.5152/TurkPediatriArs.2016.2335. eCollection 2016 Dec.

Single-pass albumin dialysis in a child aged six months with phenobarbital poisoning

Hasan Serdar Kıhtır  1 , Hamdi Murat Yıldırım  1 , Osman Yeşilbaş  1 , Burcu Bursal Duramaz  2 , Esra Şevketoğlu  1
Affiliations
Case Reports

Single-pass albumin dialysis in a child aged six months with phenobarbital poisoning

Hasan Serdar Kıhtır et al. Turk Pediatri Ars. .

Abstract

A girl aged six months was hospitalized because of resistant seizures and was discharged with phenobarbital and carbamazepine therapy. She was admitted to a state hospital with symptoms of inability to waken and difficulty in breathing. It was learned that phenobarbital had been used incorrectly and the patient was sent to our pediatric intensive care unit because of severe phenobarbital overdose. The decision was taken for hemodialysis. Single-pass albumin dialysis was planned because phenobarbital can bind to high levels of plasma protein. The process was undertaken with 1% albumin-containing dialysate, which was prepared manually. After 6 hours of dialysis, the phenobarbital blood level measured 62 mcg/mL (>140 mcg/mL on admission) and the patient's clinical findings were markedly regressed. There are no case reports about phenobarbital overdose treated with single-pass albumin dialysis in the literature. We conclude that single-pass albumin dialysis may be a useful treatment, especially with intoxications of drugs that bind protein at high levels.

Keywords: Continuous venovenous hemodialysis; phenobarbital intoxication; single-pass albumin dialysis.

PubMed Disclaimer

Conflict of interest statement

No conflict of interest was declared by the authors.

References

    1. Sümer V, Güler E, Karanfil R, et al. Çocuk acil servisine başvuran zehirlenme olgularının geriye dönük olarak değerlendirilmesi. Türk Pediatri Arş. 2011;46:226–32. https://doi.org/10.4274/tpa.46.80. - DOI
    1. Roberts D, Buckley N. Enhanced elimination in acute barbiturate poisoning – A systematic review. Clin Toxicol. 2011;49:2–12. https://doi.org/10.3109/15563650.2010.550582. - DOI - PubMed
    1. Amitai Y, Degani Y. Treatment of phenobarbital poisoning with multiple dose activated charcoal in an infant. J Emerg Med. 1990;8:449–50. https://doi.org/10.1016/0736-4679(90)90174-T. - DOI - PubMed
    1. Seige M, Kreymann B, Jeschke B, Schweigart U, Kopp KF, Classen M. Long-term treatment of patients with acute exacerbation of chronic liver failure by albumin dialysis. Transplant Proc. 1999;31:1371–5. https://doi.org/10.1016/S0041-1345(98)02033-8. - DOI - PubMed
    1. Boonsrirat U, Tiranathanagul K, Eiam-Ong S, et al. Effective bilirubin reduction by single-pass albumindialysis in liver failure. Artif Organs. 2009;33:648–53. https://doi.org/10.1111/j.1525-1594.2009.00758.x. - DOI - PubMed

Publication types

LinkOut - more resources