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. 2016 Dec 1;17(12):5173-5177.
doi: 10.22034/APJCP.2016.17.12.5173.

Lack of Altered BECN1 Gene Expression in Iranian Patients with Acute Myeloid Leukemia

Ladan Keyvan  1 , Seyed Kazem Bidoki, Davood Zare Abdollahi, Neda Mansouri, Mehrdad Hashemi, Sa Mortazavi Tabatabaei, Hediyeh Fardmanesh, Mansour Meimandi, Seyed Majid Ayatollahi, Hasan Jalaeikhoo, Abolfazl Movafagh
Affiliations

Lack of Altered BECN1 Gene Expression in Iranian Patients with Acute Myeloid Leukemia

Ladan Keyvan et al. Asian Pac J Cancer Prev. .

Abstract

Acute myeloid leukemia (AML), one of the most prevalent leukemia types in adults, demonstrates great heterogeneity in molecular and clinical terms. Hence, there is a necessity to the mechanisms involved in AML generation in order to determine optimal treatment. This cross sectional study aimed to assess changes in BECN1 gene expression in with blood samples from 30 AML patients, compared with samples from 15 healthy persons. RNA was extracted and cDNA was synthesized and Real Time PCR applied to determine BECN1 gene expression. The results showed no significant differences in BECN1 gene expression between patients with AML and normal controls (P > 0.05). It appears that expression of BECN1 does not play a significant role in genesis of AML leukemia.

Keywords: Leukemia; BECN1; changes in gene expression.

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Figures

Figure 1
Figure 1
Results of Analysis of Real-Time RT-PCR Data in Patient and Control Groups
See this image and copyright information in PMC

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