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Comment
. 2017 Jan 25;4(1):16-19.
doi: 10.1016/j.cels.2017.01.004.

Codon Clarity or Conundrum?

Daniel P Aalberts  1 , Gregory Boël  2 , John F Hunt  3
Affiliations
Comment

Codon Clarity or Conundrum?

Daniel P Aalberts et al. Cell Syst. .

Abstract

Synonymous variations in protein-coding sequences alter protein expression dynamics, which has important implications for cellular physiology and evolutionary fitness, but disentangling the underlying molecular mechanisms remains challenging.

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Figures

Figure 1
Figure 1. Schematic diagram of mechanistic processes influencing protein expression level
Processes promoting higher expression are labeled in green, while those that attenuate expression are labelled in red. Chromosomal DNA is shown and labeled in gray, RNA transcripts in black, and nascent protein in navy blue. The co-transcriptional translation schematized here only occurs in prokaryotes, but all the same molecular mechanisms likely influence protein expression in eukaryotes with the exception of those involving direct transcription-translation coupling. The Shine-Dalgarno and ribosome standby-site stem-loop (Borujeni et al., 2014) contribute to control of translation initiation in prokaryotes, while other factors control this process in eukaryotes.
See this image and copyright information in PMC

Comment on

References

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