Increase in brain activation due to sub-tasks during driving: fMRI study using new MR-compatible driving simulator

Abstract

Background: Several studies have used functional magnetic resonance imaging (fMRI) to show that neural activity is associated with driving. fMRI studies have also elucidated the brain responses associated with driving while performing sub-tasks. It is important to note that these studies used computer mouses, trackballs, or joysticks to simulate driving and, thus, were not comparable to real driving situations. In order to overcome these limitations, we used a driving wheel and pedal equipped with an MR-compatible driving simulator (80 km/h). The subjects drove while performing sub-tasks, and we attempted to observe differences in neuronal activation.

Methods: The experiments consisted of three blocks and each block consisted of both a control phase (1 min) and a driving phase (2 min). During the control phase, the drivers were instructed to look at the stop screen and to not perform driving tasks. During the driving phase, the drivers either drove (driving only condition) or drove while performing an additional sub-task (driving with sub-task condition) at 80 km/h.

Results: Compared to when the drivers were focused only on driving, when the drivers drove while performing a sub-task, the number of activation voxels greatly decreased in the parietal area, which is responsible for spatial perception. Task-performing areas, such as the inferior frontal gyrus and the superior temporal gyrus, showed increased activation. Performing a sub-task simultaneously while driving had affected the driver's driving. The cingulate gyrus and the sub-lobar region (lentiform nucleus, caudate, insula, and thalamus), which are responsible for error monitoring and control of unnecessary movements (e.g., wheel and pedal movements), showed increased activation during driving with sub-task condition compared to driving only condition.

Conclusions: Unlike simple driving simulators (joysticks, computer mouses, or trackballs) used in previous research, the addition of a driving wheel and pedals (accelerator and brake) to the driving simulator used in this study closely represents real driving. Thus, the number of processed movements was increased, which led to an increased number of unnecessary movements that needed to be controlled. This in turn increased activation in the corresponding brain regions.

Keywords: Driving; MR-compatible driving simulator; Sub-lobar; Sub-task (additional task); fMRI.

Fig. 1

a MR-compatible driving simulator consisting of driving wheel, accelerator, and brake. b Driving environment (Lightrock Entertainment Inc., S/W). c Preparation before the experiment

Fig. 2

The functional magnetic resonance imaging (fMRI) experimental procedure

Fig. 3

Brain activation areas for a driving only condition—control, b driving with sub-task condition—control, and c sub-task only condition—control (corrected p < 0.05 s)

Fig. 4

Brain activation areas for a driving only condition—driving with sub-task condition and b driving with sub-task condition—driving only condition (corrected p < 0.05)