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Review
. 2017 Mar;8(1):46-50.
doi: 10.1007/s13193-016-0568-3. Epub 2016 Oct 27.

Growing Teratoma Syndrome

S P Kataria  1 , Ankur Nandan Varshney  1 , Mukesh Nagar  1 , A K Mandal  2 , Vidya Jha  2
Affiliations
Review

Growing Teratoma Syndrome

S P Kataria et al. Indian J Surg Oncol. 2017 Mar.

Abstract

Growing teratoma syndrome, a disease characterized by presence of benign metastasis increasing in size and number after chemotherapy, is infrequent occurrence. Being unfamiliar with the disease entity, many oncologists misinterpret it as disease progression. Though the exact etio-pathognesis of the disease is still unidentified, but clinical characteristics are well defined. Being a chemo and radio-resistant disease, surgery offers only cure. We present a case of ovarian immature teratoma, who after chemotherapy presented with increased tumor size. Resected specimen confirms the diagnosis of mature teratoma leading to recognition of GTS. Surgery resulted in cure.

Keywords: Benign metastasis; Chemotherapeutic retroconversion; Growing teratoma syndrome; Teratoma.

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Conflict of interest statement

The authors declare that they have no conflict of interest. Source of Funding None

Figures

Fig. 1
Fig. 1
a Showing CECT pre-chemo revealing an ovarian mass predominantly solid with multiple septae and cysts, with specs of calcification while b shows post-chemo CECT showing ovarian mass with calcification with involvement of rectosigmoid, large sub-phrenic deposits suggestive of increase in size of mass as compared to previous scan
Fig. 2
Fig. 2
a Displaying primitive neuroectodermal tissue. Blue arrows show formation of rossettes. b Showed mature teratoma. Black arrow shows mature cartilage. Yellow arrow demonstrated glands lined by columnar epithelium and green arrows shows keratinized stratified squamous epithelium with hair follicle
See this image and copyright information in PMC

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