Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan 23:12:7.
doi: 10.1186/s13027-017-0120-2. eCollection 2017.

Clinical and prognostic analysis of 78 patients with human immuno-deficiency virus associated non-Hodgkin's lymphoma in Chinese population

Yang Shen #  1 , Renfang Zhang #  2 , Li Liu  2 , Yinzhong Shen  2 , Wei Song  2 , Tangkai Qi  2 , Yang Tang  2 , Zhenyan Wang  2 , Liqian Guan  2 , Hongzhou Lu  2
Affiliations

Clinical and prognostic analysis of 78 patients with human immuno-deficiency virus associated non-Hodgkin's lymphoma in Chinese population

Yang Shen et al. Infect Agent Cancer. .

Abstract

Background: Human Immuno-deficiency Virus (HIV) associated non-Hodgkin's lymphoma (NHL) was a special group of disease, which manifests distinct clinical features and prognosis as compared with NHLs in patients without HIV. We performed this study to describe the clinical features of the disease and investigated the potential prognostic factors.

Methods: HIV-infected patients who were newly diagnosed with NHL were enrolled in this study. The selection of anti-lymphoma treatment regimen was mainly dependent on the pathological subtypes of NHLs. Tumor response was reviewed and classified according to the International Workshop Criteria.

Results: A total of 78 patients were enrolled, among whom, 42 (53.8%) were with Diffuse large B cell Lymphoma (DLBCL), and 29 (37.2%) were with Burkitt lymphoma (BL). BL patients presented with higher risk features as compared with DLBCL in terms of numbers of extranodal diseases (P = 0.004) and poor Eastern cooperative oncology group (ECOG) score (P = 0.038). The estimated 2-year overall survival (OS) and progression free survival (PFS) rate was 74.3 ± 8.1%, 28.9 ± 11.0%, and 54.2 ± 8.1%, 19.2 ± 7.5% for DLBCL and BL, respectively. In multivariate analysis, international prognostic index (IPI) score was an independent prognostic factor for predicting both OS (OR = 2.172, 95% CI 1.579-2.987, P < 0.001) and PFS (OR = 1.838, 95% CI 1.406-2.402, P < 0.001).

Conclusions: HIV associated NHLs represents a group of heterogeneous aggressive diseases with poor prognosis. IPI parameters were still effective in predicting the prognosis of HIV associated NHLs.

Keywords: Human immuno-deficiency virus; International prognostic index; Lymphoma; Prognosis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Kaplan-Meier curves for overall survival (OS) and progression free survival (PFS) of treated patients. a OS, (b) PFS
Fig. 2
Fig. 2
Univariate analysis of potential prognostic clinical factors. a, b Ann Arbor stage for OS and PFS. c, d Extranodal Diseases for OS and PFS
Fig. 3
Fig. 3
The usefulness of ECOG and IPI in predicting the prognosis of patients. a, b ECOG performance status for OS and PFS. c, d IPI for OS and PFS
See this image and copyright information in PMC

References

    1. Gopal S, Patel MR, Yanik EL, Cole SR, Achenbach CJ, Napravnik S, et al. Temporal trends in presentation and survival for HIV-associated lymphoma in the antiretroviral therapy era. J Natl Cancer Inst. 2013;105(16):1221–9. doi: 10.1093/jnci/djt158. - DOI - PMC - PubMed
    1. Weiss R, Mitrou P, Arasteh K, Schuermann D, Hentrich M, Duehrsen U, et al. Acquired immunodeficiency syndrome-related lymphoma: simultaneous treatment with combined cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy and highly active antiretroviral therapy is safe and improves survival--results of the German Multicenter Trial. Cancer. 2006;106(7):1560–8. doi: 10.1002/cncr.21759. - DOI - PubMed
    1. Navarro JT, Vall-Llovera F, Mate JL, Morgades M, Feliu E, Ribera JM. Decrease in the frequency of meningeal involvement in AIDS-related systemic lymphoma in patients receiving HAART. Haematologica. 2008;93(1):149–50. doi: 10.3324/haematol.11767. - DOI - PubMed
    1. Wolf T, Brodt HR, Fichtlscherer S, Mantzsch K, Hoelzer D, Helm EB, et al. Changing incidence and prognostic factors of survival in AIDS-related non-Hodgkin’s lymphoma in the era of highly active antiretroviral therapy (HAART) Leuk Lymphoma. 2005;46(2):207–15. doi: 10.1080/10428190400015733. - DOI - PubMed
    1. Carroll V, Garzino-Demo A. HIV-associated lymphoma in the era of combination antiretroviral therapy: shifting the immunological landscape. Pathog Dis. 2015;73(7):ftv044. - PMC - PubMed

LinkOut - more resources