Cryo-EM Captures the Dynamics of Ion Channel Opening
- PMID: 28129535
- DOI: 10.1016/j.cell.2017.01.011
Cryo-EM Captures the Dynamics of Ion Channel Opening
Abstract
In this issue of Cell, Hite and MacKinnon (2017) report the open conformation structure of Slo2.2, a neuronal Na+-activated K+ channel. More importantly, 3D classification of electron cryomicroscopy (cryo-EM) images allows visualization of the structural transition that occurs as the open probability of individual channels increases with added sodium.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Structural Titration of Slo2.2, a Na+-Dependent K+ Channel.Cell. 2017 Jan 26;168(3):390-399.e11. doi: 10.1016/j.cell.2016.12.030. Epub 2017 Jan 19. Cell. 2017. PMID: 28111072 Free PMC article.
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