Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr:45:1-7.
doi: 10.1016/j.ceb.2016.12.009. Epub 2017 Jan 24.

Interaction between epigenetic and metabolism in aging stem cells

Anne Brunet  1 , Thomas A Rando  2
Affiliations
Review

Interaction between epigenetic and metabolism in aging stem cells

Anne Brunet et al. Curr Opin Cell Biol. 2017 Apr.

Abstract

Aging is accompanied by a decline in tissue function, regeneration, and repair. A large part of this decline is caused by the deterioration of tissue stem cell function. Understanding the mechanisms that drive stem cell aging and how to counteract them is a critical step for enhancing tissue repair and maintenance during aging. Emerging evidence indicates that epigenetic modifiers and metabolism regulators interact to impact lifespan, suggesting that this mechanism may also affect stem cell function with age. This review focuses on the interaction between chromatin and metabolism in the regulation of tissue stem cells during aging. We also discuss how these mechanisms integrate environmental stimuli such as nutrient stress to regulate stem cell function. Finally, this review examines new perspectives for regeneration, rejuvenation, and treatment of age-related decline of stem cell function.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Changes in metabolism could have long-lasting impact on stem cell function
Figure 2
Figure 2. Metabolites are co-factors of many chromatin regulators, thereby directly connecting metabolic state with chromatin state
Figure 3
Figure 3. Dietary control of regulators of stem cell function and consequences for tissue aging
See this image and copyright information in PMC

References

    1. Goodell MA, Rando TA. Stem cells and healthy aging. Science. 2015;350:1199–1204. - PubMed
    1. Benayoun BA, Pollina EA, Brunet A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol. 2015;16:593–610. - PMC - PubMed
    1. Sen P, Shah PP, Nativio R, Berger SL. Epigenetic Mechanisms of Longevity and Aging. Cell. 2016;166:822–839. - PMC - PubMed
    1. Booth LN, Brunet A. The Aging Epigenome. Mol Cell. 2016;62:728–744. - PMC - PubMed
    1. Pal S, Tyler JK. Epigenetics and aging. Sci Adv. 2016;2:e1600584. - PMC - PubMed