Interaction between epigenetic and metabolism in aging stem cells
- PMID: 28129586
- PMCID: PMC5482778
- DOI: 10.1016/j.ceb.2016.12.009
Interaction between epigenetic and metabolism in aging stem cells
Abstract
Aging is accompanied by a decline in tissue function, regeneration, and repair. A large part of this decline is caused by the deterioration of tissue stem cell function. Understanding the mechanisms that drive stem cell aging and how to counteract them is a critical step for enhancing tissue repair and maintenance during aging. Emerging evidence indicates that epigenetic modifiers and metabolism regulators interact to impact lifespan, suggesting that this mechanism may also affect stem cell function with age. This review focuses on the interaction between chromatin and metabolism in the regulation of tissue stem cells during aging. We also discuss how these mechanisms integrate environmental stimuli such as nutrient stress to regulate stem cell function. Finally, this review examines new perspectives for regeneration, rejuvenation, and treatment of age-related decline of stem cell function.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Figures



References
-
- Goodell MA, Rando TA. Stem cells and healthy aging. Science. 2015;350:1199–1204. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical