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Comment
. 2017 Mar;19(2):226-229.
doi: 10.1016/j.jmoldx.2017.01.001. Epub 2017 Jan 24.

Precision Medicine Requires Precision Laboratories

Mangalathu S Rajeevan  1 , Tengguo Li  1 , Elizabeth R Unger  2
Affiliations
Comment

Precision Medicine Requires Precision Laboratories

Mangalathu S Rajeevan et al. J Mol Diagn. 2017 Mar.

Abstract

This commentary highlights the validation study by Lih et al that supports the use of precision medicine for improved clinical trials.

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Comment on

References

    1. Lih CJ, Harrington RD, Sims DJ, Harper KN, Bouk CH, Datta V, Yau J, Singh RR, Routbort MJ, Luthra R, Patel KP, Mantha GS, Krishnamurthy S, Ronski K, Walther Z, Finberg KE, Canosa S, Robinson H, Raymond A, Le LP, McShane LM, Polley EC, Conley BA, Doroshow JH, Iafrate AJ, Sklar JL, Hamilton SR, Williams PM. Analytical Validation of the Next Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial: Molecular Analysis for Therapy CHoice Clinical Trial (NCI-MATCH, EAY131) J Mol Diagn. 2017 - PMC - PubMed
    1. Singh RR, Luthra R, Routbort MJ, Patel KP, Medeiros LJ. Implementation of next generation sequencing in clinical molecular diagnostic laboratories: advantages, challenges and potential. Expert Rev of Precis Med Drug Dev. 2016;1:109–120.
    1. Aziz N, Zhao Q, Bry L, Driscoll DK, Funke B, Gibson JS, Grody WW, Hegde MR, Hoeltge GA, Leonard DGB, Merker JD, Nagarajan R, Palicki LA, Robetorye RS, Schrijver I, Weck KE, Voelkerding KV. College of American Pathologists’ laboratory standards for next-generation sequencing clinical tests. Arch Pathol Lab Med. 2015;139:481–493. - PubMed
    1. Rehm HL, Bale SJ, Bayrak-Toydemir P, Berg JS, Brown KK, Deignan JL, Friez MJ, Funke BH, Hegde MR, Lyon E. Working Group of the American College of Medical Genetics and Genomics Laboratory Quality Assurance Commitee ACMG clinical laboratory standards for next-generation sequencing. Genet Med. 2013;15:733–747. - PMC - PubMed
    1. Gargis AS, Kalman L, Berry MW, Bick DP, Dimmock DP, Hambuch T, Lu F, Lyon E, Voelkerding KV, Zehnbauer BA, Agarwala R, Bennett SF, Chen B, Chin EL, Compton JG, Das S, Farkas DH, Ferber MJ, Funke BH, Furtado MR, Ganova-Raeva LM, Geigenmüller U, Gunselman SJ, Hegde MR, Johnson PL, Kasarskis A, Kulkarni S, Lenk T, Liu CS, Manion M, Manolio TA, Mardis ER, Merker JD, Rajeevan MS, Reese MG, Rehm HL, Simen BB, Yeakley JM, Zook JM, Lubin IM. Assuring the quality of next-generation sequencing in clinical laboratory practice. Nat Biotechnol. 2012;30:1033–1036. - PMC - PubMed

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