Review
doi: 10.1016/j.ecl.2016.09.013.
Epub 2016 Dec 14.
Fibroblast Growth Factor 23-Mediated Bone Disease
Affiliations
- PMID: 28131132
- DOI: 10.1016/j.ecl.2016.09.013
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Review
Fibroblast Growth Factor 23-Mediated Bone Disease
Endocrinol Metab Clin North Am.
2017 Mar.
Abstract
Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.
Keywords: FGF23; Hyperphosphatemia; Hypophosphatemia; Osteomalacia; Rickets; α-Klotho.
Copyright © 2016 Elsevier Inc. All rights reserved.
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