[GALECTIN-3 LEVEL IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND OBESITY OF DIFFERENT GRADE OF SEVERITY: LINK WITH ANTHROPOMETRY]

Abstract

The im is to estimate the concentration of galectin-3 in patients with acute myocardial infarction depending on the presence of overweight and obesity of different severity, as well as to analyze the character of the relationship of this parameter with the anthropometric indices. The study involved 78 patients with acute myocardial infarction. The study group included 55 patients with acute myocardial infarction and concomitant obesity. The control group consisted of 23 patients with acute myocardial infarction and normal body weight. Patients of the main group were divided according to the degree of severity of obesity. Obesity of I degree was detected in 26 individuals, II-III degrees - in 17 persons. Overweight was defined in 12 patients. It has been established that the presence and progression of obesity in patients with acute myocardial infarction accompanied by hyperactivity of pro-inflammatory mediator galectin-3, peaking in obese II-III degrees provided abdominal type of fat distribution. Overweight in turn, was not associated with a marked increased of galectin-3 production compared to those with normal weight.