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Review
. 2017 Feb;32(1):73-77.
doi: 10.1007/s00455-016-9778-7. Epub 2017 Jan 28.

Animal Models for Dysphagia Studies: What Have We Learnt So Far

Rebecca Z German  1 , A W Crompton  2 , Francois D H Gould  3 , Allan J Thexton  4
Affiliations
Review

Animal Models for Dysphagia Studies: What Have We Learnt So Far

Rebecca Z German et al. Dysphagia. 2017 Feb.

Abstract

Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in and day out care about this work? Results from studies of animal models have the potential to change and grow how we think about dysphagia research and practice in general, well beyond applying specific results to human studies. Animal research provides two key contributions to our understanding of dysphagia. The first is a more complete characterization of the physiology of both normal and pathological swallow than is possible in human subjects. The second is suggesting of specific, physiological, targets for development and testing of treatment interventions to improve dysphagia outcomes.

Keywords: Animal models; Deglutition; Deglutition disorders; Pathophysiology; Performance.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Dysphagia flow chart.
Figure 2
Figure 2
Components of underlying physiology that generate performance failure.
Figure 3
Figure 3
Relationship among underlying components for both normal and pathologic function.
See this image and copyright information in PMC

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