Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct;29(10):1243-1254.
doi: 10.1080/09540121.2017.1282108. Epub 2017 Jan 29.

Growing challenges for HIV programmes in Asia: clinic population trends, 2003-2013

Nicole L De La Mata  1 , Nagalingeswaran Kumarasamy  2 , Penh Sun Ly  3 , Oon Tek Ng  4 , Kinh Van Nguyen  5 , Tuti Parwati Merati  6 , Man Po Lee  7 , Cuong Duy Do  8 , Jun Yong Choi  9 , Jeremy L Ross  10 , Matthew G Law  1
Affiliations

Growing challenges for HIV programmes in Asia: clinic population trends, 2003-2013

Nicole L De La Mata et al. AIDS Care. 2017 Oct.

Abstract

The scale-up of antiretroviral therapy (ART) has led to a substantial change in the clinical population of HIV-positive patients receiving care. We describe the temporal trends in the demographic and clinical characteristics of HIV-positive patients initiating ART in 2003-13 within an Asian regional cohort. All HIV-positive adult patients that initiated ART between 2003 and 2013 were included. We summarized ART regimen use, age, CD4 cell count, HIV viral load, and HIV-related laboratory monitoring rates during follow-up by calendar year. A total of 16 962 patients were included in the analysis. Patients in active follow-up increased from 695 patients at four sites in 2003 to 11,137 patients at eight sites in 2013. The proportion of patients receiving their second or third ART regimen increased over time (5% in 2003 to 29% in 2013) along with patients aged ≥50 years (8% in 2003 to 18% in 2013). Concurrently, CD4 monitoring has remained stable in recent years, whereas HIV viral load monitoring, although varied among the sites, is increasing. There have been substantial changes in the clinical and demographic characteristics of HIV-positive patients receiving ART in Asia. HIV programmes will need to anticipate the clinical care needs for their aging populations, expanded viral load monitoring, and, the eventual increase in second and third ART regimens that will lead to higher costs and more complex drug procurement needs.

Keywords: ART; Asia; HIV; characteristics; clinical; demographics.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Over time, the (A) ART regimen use and (B) Age of patients, across all sites during follow-up from ART initiation.
Figure 2
Figure 2
Over time, the (A) current CD4 cell count (cells/µL) and (B) HIV viral load (copies/mL), across all sites during follow-up from ART initiation.
Figure 3
Figure 3
Testing rates (per person-year) for patients across all sites during follow-up: (A) CD4 cell count and (B) HIV viral load.
Figure 4
Figure 4
Hepatitis testing for patients across all sites during follow-up: (A) Hepatitis B and (B) Hepatitis C.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Antiretroviral Therapy Cohort, C. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372(9635):293–299. - PMC - PubMed
    1. Arnedo M, Alonso E, Eisenberg N, Ibanez L, Ferreyra C, Jaen A, Busia ORSG. Monitoring HIV viral load in resource limited settings: still a matter of debate? PLoS One. 2012;7(12):e47391. - PMC - PubMed
    1. Ball SC. The aging HIV population. Clinical Practice. 2014;11(2):221–231.
    1. Benator DA, Elmi A, Rodriguez MD, Gale HB, Kan VL, Hoffman HJ, Squires L. True durability: HIV virologic suppression in an urban clinic and implications for timing of intensive adherence efforts and viral load monitoring. AIDS Behav. 2015;19(4):594–600. - PMC - PubMed
    1. Bonner K, Mezochow A, Roberts T, Ford N, Cohn J. Viral Load Monitoring as a Tool to Reinforce Adherence: A Systematic Review. Jaids-Journal of Acquired Immune Deficiency Syndromes. 2013;64(1):74–78. - PubMed

Substances