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. 2017 May;60(5):549-555.
doi: 10.1016/j.jadohealth.2016.12.004. Epub 2017 Jan 26.

Young Transgender Women's Attitudes Toward HIV Pre-exposure Prophylaxis

Affiliations

Young Transgender Women's Attitudes Toward HIV Pre-exposure Prophylaxis

Sarah M Wood et al. J Adolesc Health. 2017 May.

Abstract

Purpose: Our primary aim was to explore themes regarding attitudes toward HIV pre-exposure prophylaxis (PrEP) among young transgender women (YTW), in order to develop a theoretical model of PrEP uptake in this population disproportionally affected by HIV.

Methods: Qualitative study nested within a mixed-method study characterizing barriers and facilitators to health services for YTW. Participants completed an in-depth interview exploring awareness of and attitudes toward PrEP. Key themes were identified using a grounded theory approach.

Results: Participants (n = 25) had a mean age of 21.2 years (standard deviation 2.2, range 17-24) and were predominately multiracial (36%) and of HIV-negative or unknown status (68%). Most participants (64%) reported prior knowledge of PrEP, and 28% reported current use or intent to use PrEP. Three major content themes that emerged were variability of PrEP awareness, barriers and facilitators to PrEP uptake, and emotional benefits of PrEP. Among participants without prior PrEP knowledge, participants reported frustration that PrEP information has not been widely disseminated to YTW, particularly by health care providers. Attitudes toward PrEP were overwhelmingly positive; however, concerns were raised regarding barriers including cost, stigma, and adherence challenges. Both HIV-positive and negative participants discussed emotional and relationship benefits of PrEP, which were felt to extend beyond HIV prevention alone.

Conclusions: A high proportion of YTW in this study had prior knowledge of PrEP, and attitudes toward PrEP were positive among participants. Our findings suggest several domains to be further explored in PrEP implementation research, including methods of facilitating PrEP dissemination and emotional motivation for PrEP uptake.

Keywords: HIV pre-exposure prophylaxis; HIV prevention; Qualitative research; Transgender women.

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Conflict of interest statement

Conflicts of Interest: No authors have conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Integrated Behavioral Model (IBM)
Figure 2
Figure 2
Integrated Model of PrEP Uptake in Young Transgender Women

References

    1. Grant RM, et al. Uptake of pre-exposure prophylaxis, sexual practices, and HIV incidence in men and transgender women who have sex with men: a cohort study. Lancet Infect Dis. 14(9):820–9. - PMC - PubMed
    1. McCormack S, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2015 - PMC - PubMed
    1. Grant RM, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med. 2010;363(27):2587–99. - PMC - PubMed
    1. Department of Health and Human Services, editor. Panel on Antiretroviral Guidelines for Adults and Adolescents, Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. 2016. pp. 1–288.
    1. U.S. Public Health Service. Pre-exposure Prophylaxis for the Prevention of HIV in the United States: A Clinical Practice Guideline. 2014. pp. 1–67.