Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits
- PMID: 28133606
- PMCID: PMC5241447
- DOI: 10.1155/2017/3795950
Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits
Abstract
Ovarian failure is related to dyslipidemias and inflammation, as well as to hypertrophy and dysfunction of the visceral adipose tissue (VAT). Although hypothyroidism has been associated with obesity, dyslipidemias, and inflammation in humans and animals, its influence on the characteristics of ovarian follicles in adulthood is scarcely known. Control and hypothyroid rabbits were used to analyze the ovarian follicles, expression of aromatase in the ovary, serum concentration of lipids, leptin, and uric acid, size of adipocytes, and infiltration of macrophages in the periovarian VAT. Hypothyroidism did not affect the percentage of functional or atretic follicles. However, it reduced the size of primary, secondary, and tertiary follicles considered as large and the expression of aromatase in the ovary. This effect was associated with high serum concentrations of total cholesterol and low-density lipoprotein cholesterol (LDL-C). In addition, hypothyroidism induced hypertrophy of adipocytes and a major infiltration of CD68+ macrophages into the periovarian VAT. Our results suggest that the reduced size of ovarian follicles promoted by hypothyroidism could be associated with dyslipidemias, hypertrophy, and inflammation of the periovarian VAT. Present findings may be useful to understand the influence of hypothyroidism in the ovary function in adulthood.
Conflict of interest statement
Authors disclose that there are no financial or personal relationships with other people or organizations that could inappropriately bias or influence this work.
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References
-
- Luque-Ramírez M., Álvarez-Blasco F., Uriol Rivera M. G., Escobar-Morreale H. F. Serum uric acid concentration as non-classic cardiovascular risk factor in women with polycystic ovary syndrome: effect of treatment with ethinyl-estradiol plus cyproterone acetate versus metformin. Human Reproduction. 2008;23(7):1594–1601. doi: 10.1093/humrep/den095. - DOI - PubMed
-
- Mannerås-Holm L., Leonhardt H., Kullberg J., et al. Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance. Journal of Clinical Endocrinology and Metabolism. 2011;96(2):E304–E311. doi: 10.1210/jc.2010-1290. - DOI - PubMed
-
- Huang Z. H., Manickam B., Ryvkin V., et al. PCOS is associated with increased CD11c expression and crown-like structures in adipose tissue and increased central abdominal fat depots independent of obesity. The Journal of Clinical Endocrinology and Metabolism. 2013;98(1):E17–E24. doi: 10.1210/jc.2012-2697. - DOI - PMC - PubMed
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