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. 2017 Jan 30:7:41637.
doi: 10.1038/srep41637.

Impact of small vessel disease in the brain on gait and balance

Daniela Pinter  1 , Stuart J Ritchie  2   3 , Fergus Doubal  2   4 , Thomas Gattringer  1 , Zoe Morris  4   5 , Mark E Bastin  4   5 , Maria Del C Valdés Hernández  4   5 , Natalie A Royle  4   5 , Janie Corley  2   3 , Susana Muñoz Maniega  4   5 , Alison Pattie  2   3 , David A Dickie  4   5 , Julie Staals  6 , Alan J Gow  2   7 , John M Starr  2   8 , Ian J Deary  2   3 , Christian Enzinger  1   9 , Franz Fazekas  1 , Joanna Wardlaw  2   4   5
Affiliations

Impact of small vessel disease in the brain on gait and balance

Daniela Pinter et al. Sci Rep. .

Abstract

Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in the elderly. We analysed 678 community-dwelling healthy subjects from the Lothian Birth Cohort 1936 at the age of 71-74 years who had undergone comprehensive risk factor assessment, gait and balance assessment as well as brain MRI. We investigated the impact of individual SVD markers (white matter hyperintensity - WMH, microbleeds, lacunes, enlarged perivascular spaces, brain atrophy) as seen on structural brain MRI and of a global SVD score on the patients' performance. A regression model revealed that age, sex, and hypertension significantly explained gait speed. Among SVD markers white matter hyperintensity (WMH) score or volume were additional significant and independent predictors of gait speed in the regression model. A similar association was seen with the global SVD score. Our study confirms a negative impact of SVD-related morphologic brain changes on gait speed in addition to age, sex and hypertension independent from brain atrophy. The presence of WMH seems to be the major driving force for SVD on gait impairment in healthy elderly subjects.

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Conflict of interest statement

The authors declare no competing financial interests.

References

    1. van der Holst H. M. et al.. Factors Associated With 8-Year Mortality in Older Patients With Cerebral Small Vessel Disease. JAMA Neurol. 73, 402–409 (2016). - PubMed
    1. Snijders A. H., van de Warrenburg B. P., Giladi N. & Bloem B. R. Neurological gait disorders in elderly people: clinical approach and classification. Lancet Neurol 6, 63–74 (2007). - PubMed
    1. Verghese J. et al.. Epidemiology of gait disorders in community-residing older adults. J. Am. Geriatr. Soc. 54, 255–261 (2006). - PMC - PubMed
    1. Mahlknecht P. et al.. Prevalence and Burden of Gait Disorders in Elderly Men and Women Aged 60–97 Years: A Population-Based Study. PLoS One 8, 1–7 (2013). - PMC - PubMed
    1. de Souza Moreira B., Sampaio R., Cavalcanti Furtado S., Dias R. & Kirkwood R. The Relationship between Diabetes Mellitus, Geriatric Syndromes, Physical Function, and Gait: A Review of the Literature. Curr Diab Rev 2015 (2015). - PubMed

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