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. 2017 Feb 22:440-441:1-9.
doi: 10.1016/j.carres.2017.01.006. Epub 2017 Jan 13.

C-5a-substituted validamine type glycosidase inhibitors

Michael Schalli  1 , Andreas Wolfsgruber  1 , Andres Gonzalez Santana  2 , Christina Tysoe  2 , Roland Fischer  3 , Arnold E Stütz  4 , Martin Thonhofer  1 , Stephen G Withers  2
Affiliations

C-5a-substituted validamine type glycosidase inhibitors

Michael Schalli et al. Carbohydr Res. .

Abstract

A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-galactosidases as well as β-glucosidases.

Keywords: Aminocyclitol; Carbasugar; Glycosidase inhibitor.

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