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Comment
. 2017 Mar 1;81(5):e35-e37.
doi: 10.1016/j.biopsych.2016.12.018.

More Than a Gut Feeling: The Implications of the Gut Microbiota in Psychiatry

Pochu Ho  1 , David A Ross  2
Affiliations
Comment

More Than a Gut Feeling: The Implications of the Gut Microbiota in Psychiatry

Pochu Ho et al. Biol Psychiatry. .
No abstract available

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Conflict of interest statement

Disclosures

The authors report no biomedical financial interests or potential conflicts of interest.

Figures

Figure 1
Figure 1
The gut-brain axis. Gut microbiota communicates with the brain by different mechanisms, including (1) direct activation of the vagus nerve; (2) by producing molecules, such as short-chain fatty acids, that may cause gut epithelium to be “leaky” and then act on a range of other systems; (3) by directly producing or altering the synthesis of neurotransmitters, including serotonin, and; (4) activating immune signaling pathways, including the release of cytokines and other inflammatory molecules. Stress, as signaled via the hypothalamic-pituitary-adrenal (HPA) axis, is one top-down mechanism that may affect gut microbiota. [Based on data from Cryan and Dinan (10).]
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References

    1. Sherwin E, Sandhu KV, Dinan TG, Cryan JF. May the force be with you: The light and dark sides of the microbiota–gut–brain axis in neuropsychiatry. CNS Drugs. 2016;30:1019–1041. - PMC - PubMed
    1. Slattery J, MacFabe DF, Frye RE. The significance of the enteric microbiome on the development of childhood disease: A review of prebiotic and probiotic therapies in disorders of childhood. Clin Med Insights Pediatr. 2016;10:91–107. - PMC - PubMed
    1. Beaumont W. Experiments and observations on the gastric juice and the physiology of digestion. Plattsburg: F.P. Allen; 1833. - PubMed
    1. Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignaca HM, Dinan TC, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108:16050–16055. - PMC - PubMed
    1. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015;162:264–276. - PMC - PubMed

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