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Comment
. 2017 Feb 7;114(6):E908-E909.
doi: 10.1073/pnas.1619059114. Epub 2017 Jan 30.

Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis

Catharina C Gross  1 , Gerd Meyer Zu Hörste  2 , Andreas Schulte-Mecklenbeck  2 , Luisa Klotz  2 , Sven G Meuth  2 , Heinz Wiendl  1
Affiliations
Comment

Reply to Liu et al.: Haplotype matters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis

Catharina C Gross et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

C.C.G. received speaker honoraria and travel expenses for attending meetings from Bayer Health Care, Genzyme, and Novartis Pharma GmbH. L.K. received speaker honoraria and travel expenses for attending meetings and financial research support from Biogen Idec, Genyzme, Novartis, and Sanofi-Aventis. S.G.M. has received honoraria for lecturing and travel expenses for attending meetings and has received financial research support from Bayer, Bayer Schering, Biogen Idec, Genzyme, Merck Serono, Merck Sharp & Dohme, Novartis, Novo Nordisk, Sanofi-Aventis, and Teva. H.W. received compensation for serving on Scientific Advisory Boards/Steering Committees for Bayer Healthcare, Biogen, Genzyme, Merck Serono, Novartis, and Sanofi Aventis. He also received speaker honoraria and travel support from Bayer Vital GmbH, Bayer Schering AG, Biogen, CSL Behring, Fresenius Medical Care, Genzyme, Glaxo Smith Kline, GW Pharmaceuticals, Lundbeck, Merck Serono, Omniamed, Novartis, and Sanovi Aventis; and has received compensation as a consultant from Biogen, Merck Serono, Novartis, and Sanofi Aventis. H.W. received research support from Bayer Vital, Biogen, Genzyme Merck Serono, Novartis, Sanofi Aventis Germany, and Sanofi US.

Comment on

References

    1. Gross CC, et al. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci USA. 2016;113(21):E2973–E2982. - PMC - PubMed
    1. Piédavent-Salomon M, et al. Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function. Brain. 2015;138(Pt 11):3263–3274. - PubMed
    1. Hafler JP, et al. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun. 2009;10(1):5–10. - PMC - PubMed
    1. Wieczorek S, et al. Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener’s granulomatosis and confirmation for multiple sclerosis in German patients. Genes Immun. 2009;10(6):591–595. - PubMed
    1. Alcina A, et al. The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis. Genes Immun. 2010;11(5):439–445. - PubMed

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