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. 2016 Dec 1;6(4):209-216.
eCollection 2016 Dec.

Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA

A Sinha  1 , H K Patni  2 , B M Dixit  1 , N K Painuly  3 , N Singh  3
Affiliations

Estimation of Photon Specific Absorbed Fractions in Digimouse Voxel Phantom using Monte Carlo Simulation Code FLUKA

A Sinha et al. J Biomed Phys Eng. .

Abstract

Background: Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs.

Objective: SAF values for monoenergetic photons of energies 15, 50, 100, 500, 1000 and 4000 keV were evaluated for the Digimouse voxel phantom incorporated in Monte Carlo code FLUKA. The organ sources considered in this study were lungs, skeleton, heart, bladder, testis, stomach, spleen, pancreas, liver, kidney, adrenal, eye and brain. The considered target organs were lungs, skeleton, heart, bladder, testis, stomach, spleen, pancreas, liver, kidney, adrenal and brain. Eye was considered as a target organ only for eye as a source organ. Organ compositions and densities were adopted from International Commission on Radiological Protection (ICRP) publication number 110.

Results: Evaluated organ masses and SAF values are presented in tabular form. It is observed that SAF values decrease with increasing the source-to-target distance. The SAF value for self-irradiation decreases with increasing photon energy. The SAF values are also found to be dependent on the mass of target in such a way that higher values are obtained for lower masses. The effect of composition is highest in case of target organ lungs where mass and estimated SAF values are found to have larger differences.

Conclusion: These SAF values are very important for absorbed dose calculation for various organs of a mouse.

Keywords: Digimouse Voxel Phantom; FLUKA; Monte Carlo Simulation; Specific Absorbed Fraction.

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Figures

Figure1
Figure1
Digimouse Phantom Incorporated in FLUKA Code (different views)
Figure2
Figure2
Self-irradiation in Organs such as Liver, Stomach, Heart, Kidney and Pancreas
Figure3
Figure3
Cross-irradiation in Organs such as Stomach, Pancreas, Spleen, Heart and Kidney (Source: Liver)
Figure4
Figure4
Comparison of Photon Specific Absorbed Fractions for Self-irradiation in Lung and Spleen between Present Study and Mohammadi et al. Study
Figure5
Figure5
Comparison of Photon Specific Absorbed Fractions for Cross-irradiation in the Present Study and Mohammadi et al. Study (Source: Stomach)
See this image and copyright information in PMC

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