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. 2017 Feb 1:7:41370.
doi: 10.1038/srep41370.

The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis

Guyue Cheng  1 , Yamei Xu  2 , Xudong Zhu  2 , Shuyu Xie  1 , Liye Wang  2 , Lingli Huang  1 , Haihong Hao  1 , Zhenli Liu  1 , Yuanhu Pan  1 , Dongmei Chen  1 , Yulian Wang  1 , Zonghui Yuan  1   2
Affiliations

The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis

Guyue Cheng et al. Sci Rep. .

Abstract

Aditoprim (ADP) has potential use as an antimicrobial agent in animals. However, its pharmacodynamic properties have not been systematically studied yet. In this study, the in vitro antibacterial activities of ADP and its main metabolites were assayed, and the in vivo antibacterial efficacy of ADP for the treatment of swine streptococcosis was evaluated. It was shown that Salmonella and Streptococcus from swine, Escherichia coli and Salmonella from chickens, E. coli, Streptococcus, Mannheimia, Pasteurella from calves, Streptococcus and Mannheimia from sheep, and E. coli, Flavobacterium columnare, Acinetobacter baumannii and Yersinia ruckeri from fishes were highly susceptible to ADP. Haemophilus parasuis from swine, Staphylococcus aureus, Aeromonas punctate, Mycobacterium tuberculosis, Streptococcus agalactiae from fishes, and Klebsiella from calves and sheep showed moderate susceptibility to ADP, whereas E. coli, Actinobacillus pleuropneumonia, Pasteurella, S. aureus, Clostridium perfringens from swine, S. aureus, C. perfringens from chickens, and S. aureus from calves were resistant to ADP. The main metabolites of ADP showed equal activity to that of their parent compound, and the prevention and therapeutic dosages of ADP recommended for swine streptococcosis were 10 and 20~40 mg/kg b.w., respectively. This study firstly showed that ADP had strong antibacterial activity and had potential to be used as a single drug in the treatment of bacterial infectious diseases.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1. Changes in the mean rectal temperatures in each of the six groups of swine.
The infected swine were treated once daily with indicated doses of ADP or Compound Sulfadiazine Sodium (Positive control) from Day 0 to Day 5. The average rectal temperatures of the healthy (Blank) and treated or untreated (Negative control) infected swine were observed and recorded from Day 0 to Day 20.
Figure 2
Figure 2. Changes in the mean clinical scores in each of the six groups of swine.
The infected swine were treated once daily with indicated doses of ADP or Compound Sulfadiazine Sodium (Positive control) from Day 0 to Day 5. The average clinical scores of the healthy (Blank) and treated- or untreated- (Negative control) infected swine were observed and recorded from Day 0 to Day 20.
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