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. 2017 Apr;29(13).
doi: 10.1002/adma.201605594. Epub 2017 Feb 1.

Suspended Manufacture of Biological Structures

Samuel R Moxon  1 , Megan E Cooke  2   3 , Sophie C Cox  2 , Martyn Snow  2   4 , Lee Jeys  4 , Simon W Jones  3 , Alan M Smith  1 , Liam M Grover  2
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Suspended Manufacture of Biological Structures

Samuel R Moxon et al. Adv Mater. 2017 Apr.

Abstract

A method for the production of complex cell-laden structures is reported, which allows high-levels of spatial control over mechanical and chemical properties. The potential of this method for producing complicated tissues is demonstrated by manufacturing a complex hard/soft tissue interface and demonstrating that cell phenotype can be maintained over four weeks of culture.

Keywords: additive layer manufacturing; cartilage; hydrogels; osteochondral; tissue engineering.

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