Human Papillomavirus (HPV) and cervical cancer

Abstract

Cervical cancer is one of the most common cancer in women in Poland and in the world. The main risk factor for this cancer is persistent infection with high - risk human papillomavirus (HPV-HR) types. The most important role in carcinogenesis is attributed to viral oncoproteins E6 and E7, that affect some cell cycle proteins. Diagnosis of HPV infection, in which the molecular test play an important role, allow for detection on precancerous lesions of the cervix, and effective treatment of these conditions. The application of modern diagnostic tests and vaccination against HPV may in the future lead to a reduction in the incidence of cervical cancer.