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Review
. 2017 Jan;45(1):54-61.
doi: 10.1111/ceo.12872. Epub 2016 Dec 19.

Emerging ocular biomarkers of Alzheimer disease

Peter van Wijngaarden  1   2 , Xavier Hadoux  1   2 , Mostafa Alwan  1   2 , Stuart Keel  1   2 , Mohamed Dirani  1   2
Affiliations
Review

Emerging ocular biomarkers of Alzheimer disease

Peter van Wijngaarden et al. Clin Exp Ophthalmol. 2017 Jan.

Abstract

Interest in reliable biomarkers of Alzheimer disease, the leading cause of dementia, has been fuelled by challenges in diagnosing the disease and monitoring disease progression as well as the response to therapy. A range of ocular manifestations of Alzheimer disease, including retinal and lens amyloid-beta accumulation, retinal nerve fiber layer loss, and retinal vascular changes, have been proposed as potential biomarkers of the disease. Herein, we examine the evidence regarding the potential value of these ocular biomarkers of Alzheimer disease.

Keywords: Alzheimer disease; amyloid beta; biomarker; ocular; retina.

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