Blunting CHIKV infection by keeping T cells in check

Philippe Gasque^{1

2}, Marie Christine Jaffar-Bandjee^{1

2

3}

Affiliations

¹ UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical, INSERM U1187, CNRS 9192, IRD 249, Université de La Réunion, Saint Denis, Réunion.
² LICE-OI, Laboratoire d'Immunologie Clinique et Expérimentale-zone Océan Indien, CHU Félix Guyon, Saint Denis, Réunion.
³ CNR-associé arbovirus, CHU Félix Guyon, Saint Denis, Réunion.

Comment

Philippe Gasque et al. Sci Transl Med. 2017.

. 2017 Feb 1;9(375):eaam6567.

doi: 10.1126/scitranslmed.aam6567.

Philippe Gasque^{1

2}, Marie Christine Jaffar-Bandjee^{1

2

3}

¹ UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical, INSERM U1187, CNRS 9192, IRD 249, Université de La Réunion, Saint Denis, Réunion.
² LICE-OI, Laboratoire d'Immunologie Clinique et Expérimentale-zone Océan Indien, CHU Félix Guyon, Saint Denis, Réunion.
³ CNR-associé arbovirus, CHU Félix Guyon, Saint Denis, Réunion.

Abstract

Modulating the host immune response ameliorates arthritic disease in mice infected with chikungunya virus (Miner et al and Teo et al).

Fingolimod treatment abrogates chikungunya virus-induced arthralgia.
Teo TH, Chan YH, Lee WW, Lum FM, Amrun SN, Her Z, Rajarethinam R, Merits A, Rötzschke O, Rénia L, Ng LF. Teo TH, et al. Sci Transl Med. 2017 Feb 1;9(375):eaal1333. doi: 10.1126/scitranslmed.aal1333. Sci Transl Med. 2017. PMID: 28148838
Therapy with CTLA4-Ig and an antiviral monoclonal antibody controls chikungunya virus arthritis.
Miner JJ, Cook LE, Hong JP, Smith AM, Richner JM, Shimak RM, Young AR, Monte K, Poddar S, Crowe JE Jr, Lenschow DJ, Diamond MS. Miner JJ, et al. Sci Transl Med. 2017 Feb 1;9(375):eaah3438. doi: 10.1126/scitranslmed.aah3438. Sci Transl Med. 2017. PMID: 28148840 Free PMC article.