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. 2016 Oct;8(5):316-320.

Evidence of human coroanvirus (229E), in patients with respiratory infection, Iran, 2015: the first report

Ali Madhi  1 , Arash Ghalyanchilangeroudi  2 , Mohammad Soleimani  1
Affiliations

Evidence of human coroanvirus (229E), in patients with respiratory infection, Iran, 2015: the first report

Ali Madhi et al. Iran J Microbiol. 2016 Oct.

Abstract

Background and objectives: Human coronaviruses (HCoVs) are one of the main causes of upper respiratory tract infections in humans. While more often responsible for mild illness, they have been associated with illnesses that require hospitalization.

Materials and methods: 270 Samples from patients hospitalized with the respiratory infection during the autumn season of 2015 were evaluated for the presence of four HCoVs (OC43, 229E, HUK1, and NL63) using an optimized SYBR green RT-PCR assay.

Results: Fifteen HCoV-229E positive samples were identified (5.5 % positive). 85% of positive samples were male with the range of age between 12- 75 years old.

Conclusion: It is the first comprehensive study on determination of the role of human coronaviruses in respiratory infections in Iran. Our data provide a novel insight into the epidemiology of HCoVs in Iran. Further studies are needed and should include the isolation and molecular characterization of HCoVs in Iran.

Keywords: 229E; HUK-1; Human coronavirus; Iran; NL63; OC43.

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References

    1. Gaunt E, Hardie A, Claas E, Simmonds P, Templeton K. Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method. J Clin Microbiol 2010;48 (8): 2940– 7. - PMC - PubMed
    1. van der Hoek L, Pyrc K, Jebbink MF, Vermeulen-Oost W, Berkhout RJ, Wolthers KC, et al. Identification of a new human coronavirus. Nat Med 2004;10 (4): 368– 73. - PMC - PubMed
    1. Woo PC, Lau SK, Yip CC, Huang Y, Yuen K-Y. More and more coronaviruses: human coronavirus HKU1. Viruses 2009;1 (1): 57– 71. - PMC - PubMed
    1. Esper F, Shapiro ED, Weibel C, Ferguson D, Landry ML, Kahn JS. Association between a novel human coronavirus and Kawasaki disease. J Infect Dis 2005;191 (4): 499– 502. - PMC - PubMed
    1. Dare RK, Fry AM, Chittaganpitch M, Sawanpanyalert P, Olsen SJ, Erdman DD. Human coronavirus infections in rural Thailand: a comprehensive study using real-time reverse-transcription polymerase chain reaction assays. J Infect Dis 2007;196 (9): 1321– 8. - PMC - PubMed

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